As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases.
【저자키워드】 SARS-CoV-2, lung cancer, natural product, United States Food and Drug Administration-approved drug, natural remedy, 【초록키워드】 COVID-19, Treatment, coronavirus disease, coronavirus, pandemic, Cancer, drugs, Remdesivir, drug, anti-SARS-CoV-2, Health, International, Lung diseases, resveratrol, mortality rate, public health emergency, monotherapy, Therapies, food, Combination, starting point, baicalein, natural, acute respiratory syndrome, contagious, celastrol, malignant tumor, widespread, highest, demonstrated, active against, individuals, 【제목키워드】 COVID-19, natural,