Coronavirus disease 2019 (COVID-19), a respiratory illness caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed over one million lives worldwide since December 2019. The complement system, while a first-line immune defense against invading pathogens, has off-target effects that lead to increases in inflammation, tissue damage, and thrombosis; these are common, life-threatening complications seen in patients with COVID-19. This review explores the potential impact of complement activation in COVID-19 and possible treatments targeting the complement system.
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【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, complement, heparin, Coagulopathy, C3, C5, compstatin, 【초록키워드】 Treatment, Coronavirus disease 2019, coronavirus, Infection, Respiratory illness, Complication, acute respiratory syndrome, Activation, tissue damage, life-threatening, invading pathogens, immune defense, Effect, caused, claimed, increases in, patients with COVID-19, 【제목키워드】 COVID, Impact, pharmacotherapy, targeting, System, Potential,
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, complement, heparin, Coagulopathy, C3, C5, compstatin, 【초록키워드】 Treatment, Coronavirus disease 2019, coronavirus, Infection, Respiratory illness, Complication, acute respiratory syndrome, Activation, tissue damage, life-threatening, invading pathogens, immune defense, Effect, caused, claimed, increases in, patients with COVID-19, 【제목키워드】 COVID, Impact, pharmacotherapy, targeting, System, Potential,