Malaria vaccines targeting merozoite invasion of erythrocytes have long held appeal but failed in clinical trials. Three structural studies of antibody-antigen complexes by Alanine et al., Urusova et al., and Rawlinson et al. define neutralizing and nonneutralizing epitopes in essential invasion proteins, leading to rational design of improved merozoite vaccines.
All Keywords
【저자키워드】 neutralizing antibody, X-ray crystallography, Epitopes, Plasmodium falciparum, Plasmodium vivax, Malaria vaccine,
【저자키워드】 neutralizing antibody, X-ray crystallography, Epitopes, Plasmodium falciparum, Plasmodium vivax, Malaria vaccine,