Abstract Background Several lifestyle-related factors, such as obesity and diabetes, have been identified as risk factors for Coronavirus disease 2019 (COVID-19) mortality. The objective of this study was to examine the global association between lifestyle-related factors and COVID-19 mortality using data from each individual country. Methods The association between prevalence of seven lifestyle-related factors (overweight, insufficient physical activity, smoking, type-2 diabetes, hypertension, hyperlipidaemia, and age over 65) and COVID-19 mortality was assessed by linear and multivariable regression among 186 countries. The cumulative effect of lifestyle-related factors on COVID-19 mortality was assessed by dividing countries into four categories according to the number of lifestyle-related factors in the upper half range and comparing the mean mortality between groups. Results In linear regression, COVID-19 mortality was significantly associated with overweight, insufficient physical activity, hyperlipidaemia, and age ≥65. In multivariable regression, overweight and age ≥65 demonstrated significant association with COVID-19 mortality ( p = .0039, .0094). Countries with more risk factors demonstrated greater COVID-19 mortality (P for trend <.001). Conclusion Lifestyle-related factors, especially overweight and elderly population, were associated with increased COVID-19 mortality on a global scale. Global effort to reduce burden of lifestyle-related factors along with protection and vaccination of these susceptible groups may help reduce COVID-19 mortality.
【저자키워드】 COVID-19, Mortality, obesity, elderly, diabetes, lifestyle-related factors, 【초록키워드】 Coronavirus disease 2019, vaccination, physical activity, smoking, risk factor, hypertension, Prevalence, Factors, Linear regression, age, group, association, COVID-19 mortality, Factor, help, effort, cumulative, type-2 diabetes, susceptible, country, Seven, multivariable, Result, greater, significantly, linear, demonstrated, reduce, category, groups, the mean, with COVID-19, 【제목키워드】 association, COVID-19 mortality, Factor,