JAK/STAT signaling plays a major role in the pathogenesis of secondary hemophagocytic lymphohistiocytosis. This case report on a critically ill patient with secondary hemophagocytic lymphohistiocytosis due to falciparum malaria treated successfully with ruxolitinib, demonstrates that JAK1/2 inhibition might be a promising treatment option for severe cases.
All Keywords
【저자키워드】 Hemophagocytosis, HLH, JAK/STAT, JAK1/2 inhibition, Malaria tropica,
【저자키워드】 Hemophagocytosis, HLH, JAK/STAT, JAK1/2 inhibition, Malaria tropica,