Background The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown. Methods The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records. Results The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death. Conclusion NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19. Trial registration ClinicalTrials, NCT04292964. Registered 03 March 2020,
【저자키워드】 COVID-19, SARS-CoV-2, outcome, NT-proBNT, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, severe COVID-19, peptide, hospitalized patients, severe acute respiratory syndrome Coronavirus, China, cardiac injury, sensitivity, specificity, outbreak, International, Patient, Case fatality rate, Factors, public health emergency, respiratory, information, NT-proBNP, Injury, best, medical records, In-hospital death, risk of death, acute respiratory syndrome, Primary outcome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, potential risk, severe COVID-19 patients, Fatality rate, cut-off value, independent risk factor, N Terminal, significantly increased, Result, enrolled, defined, predicted, analyzed, caused, hospitalized patient, correlated, ineligible, severe COVID-19 patient, with COVID-19, 【제목키워드】 Patient,