The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.
All Keywords
【저자키워드】 allele frequency, Genetic epidemiology, sickle cell, severe malaria, balanced polymorphism, hemoglobin S,
【저자키워드】 allele frequency, Genetic epidemiology, sickle cell, severe malaria, balanced polymorphism, hemoglobin S,