The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied.
All Keywords
【저자키워드】 lipophilicity, Huisgen 1,3-dipolar cycloaddition, Antiplasmodial studies, Ferrocene conjugates, Ferrocene/ferrocenium redox couple,
【저자키워드】 lipophilicity, Huisgen 1,3-dipolar cycloaddition, Antiplasmodial studies, Ferrocene conjugates, Ferrocene/ferrocenium redox couple,