Abstract Background: Hyperglycemia at admission has been demonstrated to exacerbate the outcomes of coronavirus disease 2019 (COVID-19) but a meta-analysis is lacking to further confirm this hypothesis. The purpose of this meta-analysis was to summarize the evidence on the association between hyperglycemia at admission and the development of COVID-19. Method: Four databases namely, PubMed, Web of Science, Embase and Cochrane Library, were screened for eligible studies. STATA software was utilized to pool data for this meta-analysis. The primary outcomes included mortality and severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models, and the quality of evidence was appraised by the Newcastle–Ottawa Scale (NOS). This meta-analysis was prospectively registered online on PROSPERO, CRD42020191763. Results: Sixteen observational studies with 6386 COVID-19 patients relating hyperglycemia at admission to COVID-19 outcomes were included. The overall data demonstrated that, compared with the control, the hyperglycemia at admission group was more likely to have increased mortality (OR = 3.45, 95% CI, 2.26–5.26) and severe/critical complications (OR = 2.08, 95% CI, 1.45–2.99) of COVID-19. Conclusion: Hyperglycemia at admission in COVID-19 patients may be a strong predictor of mortality and complications.
【저자키워드】 SARS-CoV-2, Coronavirus disease 2019, Mortality, complications, Glucose, hyperglycaemia, 【초록키워드】 COVID-19, coronavirus disease, Meta-analysis, severity, outcome, database, observational study, Complication, scale, hyperglycemia, Admission, association, Evidence, Hypothesis, COVID-19 patient, Web of Science, Primary outcome, 95% CI, 95% confidence interval, Cochrane Library, Registered, increased mortality, Random-effects models, Stata, screened, calculated, demonstrated, exacerbate, CIs, eligible, NOS, 【제목키워드】 COVID-19, Meta-analysis, Complication, Admission,