Estimating the case-fatality rate and clinical outcomes for patients with coronavirus disease 2019 (COVID-19) is crucial because health care systems must adequately prepare for outbreaks and design appropriate policies. A systematic search of PubMed, Embase, and Medline+Journal (via OVID) were conducted for relevant journal publications from database inception to May 4, 2020. Articles that reported the fatality rates and clinical outcomes of patients hospitalized for COVID-19 or severe acute respiratory syndrome (SARS) infection were included. Nine clinical reports (four SARS reports and five COVID-19 reports) with a total of 851 patients (367 and 484 patients with SARS and COVID-19, respectively) were analyzed. A greater proportion of hospitalized patients with COVID-19 had bilateral pneumonia (90.0% [76.3%–96.2%] vs. 35.9% [21.4%–53.6%], p < 0.001) and required ventilators (23.8% [18.8%–29.6%] vs. 15.3% [11.9%–19.4%], p = 0.010) compared with hospitalized patients with SARS. The case-fatality rate was 9.5% (6.5%–13.7%) and 6.1% (3.5%–10.3%) among patients with COVID-19 and SARS, respectively (p = 0.186). The case-fatality rate among hospitalized patients with COVID-19 was comparable to that during the 2003 SARS outbreak. A higher incidence of bilateral pneumonia and increased ventilator usage were noted among patients with COVID-19 compared with patients with SARS.
【저자키워드】 COVID-19, Severe acute respiratory syndrome (SARS), fatality, 【초록키워드】 coronavirus disease, Infection, database, Clinical outcome, outbreak, Patient, incidence, Health care system, acute respiratory syndrome, ventilator, Fatality rate, bilateral pneumonia, article, FIVE, greater, analyzed, patients with SARS, proportion, reported, required, conducted, 2003 SARS, hospitalized patient, comparable, patients hospitalized, patients with COVID-19, with COVID-19, 【제목키워드】 Meta-analysis, outcome, clinical, patients hospitalized,