Pneumococcus is themajor cause of bacterial and invasive pneumococcal infections. Disrupting the alveolarepithelial barrier is an important step in the pathogenesis of invasivepneumococcal infections. The epidermal growth factor receptor (EGFR) maintainsthe integrity of the alveolar epithelial barrier. In this study, we showed that secretory pneumococcal molecules decrease the molecular weight of EGFR without peptide degradation and inhibit alveolar epithelial cell proliferation via EGFR.
All Keywords
【저자키워드】 protease, alveolar epithelial cells, epidermal growth factor receptor, pneumococcus, glycosidase,
【저자키워드】 protease, alveolar epithelial cells, epidermal growth factor receptor, pneumococcus, glycosidase,