The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) is hitting the world hard, but the relationship between coagulation disorders and COVID-19 is still not clear. This study aimed to explore whether early coagulation tests can predict risk stratification and prognosis. PubMed, Web of Science, Cochrane Library, and Scopus were searched electronically for relevant research studies published up to March 24, 2020, producing 24 articles for the final inclusion. The pooled standard mean difference (SMD) of coagulation parameters at admission were calculated to determine severe and composite endpoint conditions (ICU or death) in COVID-19 patients. Meta-analyses revealed that platelet count was not statistically related to disease severity and composite endpoint; elevated D-dimer correlated positively with disease severity (SMD 0.787 (0.277-1.298), P= 0.003, I 2 = 96.7%) but had no significant statistical relationship with composite endpoints. Similarly, patients with prolonged prothrombin time (PT) had an increased risk of ICU and increased risk of death (SMD 1.338 (0.551-2.125), P = 0.001, I 2 = 92.7%). Besides, increased fibrin degradation products (FDP) and decreased antithrombin might also mean the disease is worsening. Therefore, early coagulation tests followed by dynamic monitoring is useful for recognizing coagulation disorders accompanied by COVID-19 and guiding timely therapy to improve prognosis.
【저자키워드】 COVID-19, Meta-analysis, Prognosis, risk, blood coagulation disorders, 【초록키워드】 therapy, disease severity, D-dimer, ICU, risk stratification, outbreak, Research, Patient, death, Platelet, Degradation, Admission, predict, COVID-19 patients, endpoints, Prothrombin time, composite endpoint, coagulation test, Web of Science, increased risk, worsening, Cochrane Library, Final, mean difference, article, Inclusion, SMD, coagulation disorder, statistical, IMPROVE, the disease, elevated, calculated, condition, searched, determine, correlated, recognizing, producing, had no, statistically, accompanied, coagulation parameter, 【제목키워드】 risk stratification, predict, coagulation test,