The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.
【저자키워드】 COVID-19, Coronavirus disease 2019, Clinical characteristics, Pneumonia, immunopathology, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), 【초록키워드】 Mortality, SARS-COV-2 infection, diagnostic, CRP, CD8, lymphocyte, early diagnosis, sensitivity, COVID-19 vaccines, COVID-19 infection, outbreak, Patient, Effectiveness, IL-8, age, public health emergency, severe pneumonia, COVID-19 patients, IL-1β, early infection, COVID-19 patient, World Health Organization, Immune system dysfunction, dysfunction, deficiency, Factor, naïve, non-severe patients, cut-off value, CD45, cut-off, non-severe cases, memory T, Affect, CD3, Non-severe case, accompanied, IL-6 level, non-severe patient, 【제목키워드】 Critical, predict, Immune cell, COVID-19 patient,