Background There is limited evidence on the characteristics and outcome of patients with dementia hospitalised for novel coronavirus infection (COVID-19). Method We conducted a prospective study in 2 gerontologic COVID units in Paris, France, from March 14, 2020, to May 7, 2020. Patients with dementia hospitalised for confirmed COVID-19 infection were systematically enrolled. A binary logistic regression analysis was performed to identify factors associated with mortality at 21 days. Results We included 125 patients. Median age was 86 (IQI 82–90); 59.4% were female. Most common causes of dementia were Alzheimer’s disease, mixed dementia and vascular dementia. 67.2% had ≥ 2 comorbidities; 40.2% lived in a long-term care facility. The most common symptoms at COVID-19 onset were confusion and delirium (82.4%), asthenia (76.8%) and fever (72.8%) before polypnea (51.2%) and desaturation (50.4%). Falls were frequent at the initial phase of the disease (35.2%). The fatality rate at 21 days was 22.4%. Chronic kidney disease and CRP at admission were independent factors of death. Persisting confusion, mood and behavioural disorders were observed in survivors (19.2%). Conclusion COVID-19 in demented individuals is associated with severe outcome in SARS-CoV-2 infection and is characterised by specific clinical features and complications, with confusion and delirium at the forefront. COVID-19 testing should be considered in front of any significant change from baseline.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, Dementia, Prognostic factors, 【초록키워드】 SARS-COV-2 infection, Prospective Study, CRP, Symptom, outcome, Alzheimer’s disease, COVID, COVID-19 testing, Characteristics, Desaturation, delirium, Fever, female, Patient, death, Kidney disease, France, complications, age, behavioural, Novel coronavirus infection, Admission, Care, patients, clinical feature, Evidence, chronic, Confusion, Factor, Logistic regression analysis, Vascular, individual, Paris, Fatality rate, Confirmed COVID-19 infection, disorder, MOST, survivor, hospitalised, independent, initial, Result, enrolled, identify, the disease, conducted, was performed, cause, baseline, Fall, 【제목키워드】 risk factor, cohort study, Patient, clinical feature,