Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has impacted heavily on global health. Although real-time polymerase chain reaction (RT-PCR) is the current diagnostic method, challenges for low- and middle-income countries (LMICs) necessitate cheaper, higher-throughput, reliable rapid diagnostic tests (RDTs). Objective We reviewed the documented performance characteristics of available COVID-19 RDTs to understand their public health utility in the ongoing pandemic, especially in resource-scarce LMIC settings. Methods Using a scoping review methodology framework, common literature databases and documentary reports were searched up to 22 April 2020, irrespective of geographical location. The search terms included ‘SARS-CoV-2 AND serological testing’ and ‘COVID-19 AND serological testing’. Results A total of 18 RDTs produced in eight countries, namely China (6; 33.33%), the United States (4; 22.22%), Germany (2; 11.11%), Singapore (2; 11.11%), Canada, Kenya, Korea and Belgium (1 each; 5.56%), were evaluated. Reported sensitivity ranged from 18.4% to 100% (average = 84.7%), whereas specificity ranged from 90.6% to 100% (average = 95.6%). The testing time ranged from 2 min to 30 min. Of the 12 validated RDTs, the IgM/IgG duo kit with non-colloidal gold labelling system was reported to elicit the highest sensitivity (98% – 100%) and specificity (98% – 99% for IgG and 96% – 99% for IgM). Conclusion We found reports of high sensitivity and specificity among the developed RDTs that could complement RT-PCR for the detection of SARS-CoV-2 antibodies, especially for screening in LMICs. However, it is necessary to validate these kits locally.
【저자키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Rapid diagnostic test, Low- and middle-income countries, 【초록키워드】 public health, IgG, IgM, Coronavirus disease 2019, pandemic, complement, RT-PCR, database, China, sensitivity, specificity, Health, SARS-CoV-2 antibodies, Characteristics, Sensitivity and specificity, RDT, Germany, IgM/IgG, Kenya, methodology, Singapore, utility, Canada, Belgium, serological, Diagnostic method, Coronavirus-2, RDTs, acute respiratory syndrome, average, geographical location, objective, country, polymerase chain, Result, produced, highest, caused, reported, the United State, evaluated, eight, searched, elicit, ranged, impacted, 【제목키워드】 Transmission, country,