Background Acute kidney injury (AKI) occurs among patients with coronavirus disease-19 (COVID-19) and has also been indicated to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment of COVID-19. We conducted a systematic review to evaluate the incidence of AKI in hospitalized COVID-19 patients. The incidence of AKI in different subgroups was also investigated. Methods A thorough search was performed to find relevant studies in PubMed, Web of Science, medRxiv and EMBASE from 1 Jan 2020 until 1 June 2020. The systematic review was performed using the meta package in R (4.0.1). Results A total of 16,199 COVID-19 patients were included in our systematic review. The pooled estimated incidence of AKI in all hospitalized COVID-19 patients was 10.0% (95% CI: 7.0–12.0%). The pooled estimated proportion of COVID-19 patients who needed continuous renal replacement therapy (CRRT) was 4% (95% CI: 3–6%). According to our subgroup analysis, the incidence of AKI could be associated with age, disease severity and ethnicity. The incidence of AKI in hospitalized COVID-19 patients being treated with remdesivir was 7% (95% CI: 3–13%) in a total of 5 studies. Conclusion We found that AKI was not rare in hospitalized COVID-19 patients. The incidence of AKI could be associated with age, disease severity and ethnicity. Remdesivir probably did not induce AKI in COVID-19 patients. Our systematic review provides evidence that AKI might be closely associated with SARS-CoV-2 infection, which should be investigated in future studies. Supplementary Information The online version contains supplementary material available at 10.1186/s12882-021-02244-x.
【초록키워드】 COVID-19, Treatment, SARS-COV-2 infection, disease severity, Remdesivir, systematic review, Kidney injury, AKI, Coronavirus disease-19, Patient, age, incidence, in-hospital mortality, COVID-19 patients, hospitalized COVID-19 patient, renal replacement therapy, Evidence, COVID-19 patient, subgroup, Web of Science, hospitalized COVID-19 patients, supplementary material, CRRT, subgroup analysis, Result, evaluate, proportion, indicated, investigated, conducted, was performed, treated, provide, occur, induce, package in R, 【제목키워드】 Acute kidney injury, AKI, incidence, subgroup analysis, patients with COVID-19,