Background A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China. Methods Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe). Results Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05). Conclusion Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.
【저자키워드】 COVID-19, Clinical characteristics, 2019-nCoV, China, Wuhan, 【초록키워드】 fatigue, disease severity, Infection, Sex, CRP, cough, COVID-19 disease, Characteristics, Coronavirus disease-19, Chest CT, Features, COVID-19 infection, outbreak, severity of COVID-19, Fever, Patient, Travel, Mild, age, morphology, change, moderate, mild infection, severe disease, COVID-19 patient, C-reactive protein (CRP, mild in severity, no difference, clinical information, serum amyloid, statistically significant difference, Severe case, human-to-human transmission, Severity of infection, no statistical difference, oxygenation index, oxyhemoglobin, MOST, parameter, feature, Course, SAA, Result, defined, evaluate, occurred, elevated, Most patient, exhibited, changes in, infected patient, two group, patients with COVID-19, 【제목키워드】 coronavirus disease, Characteristics, clinical, Patient, case control study,