Background Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients. Methods The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China. Results In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively. Conclusions Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation. Trial registration Current Controlled Trials ChiCTR2000033580 , Jun 6th 2020. Retrospectively registered.
【저자키워드】 COVID-19, SARS-CoV-2, RT-PCR, Recurrent, 【초록키워드】 coronavirus disease, IgG, coronavirus, Hospitalized, Clinical characteristics, hospital, rehabilitation, Transmission, virus, Antibody detection, RDT, Rapid diagnostic test, outbreak, Patient, Follow-up, recovered patients, serological, positive RT-PCR, acute respiratory syndrome, throat swabs, specimen, Registered, positive, throat swab, current, Wuhan, China, recovered patient, Result, hospitalized patient, Controlled, 【제목키워드】 Retrospective study, Wuhan, positive RT-PCR, recovered COVID-19 patient,