Background Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early. Methods In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve. Results Significantly, disease severity was associated with age ( r = 0.458, P < 0.001), comorbidities ( r = 0.445, P < 0.001), white cell count ( r = 0.229, P = 0.006), neutrophil count ( r = 0.238, P = 0.004), lymphocyte count ( r = − 0.295, P < 0.001), albumin ( r = − 0.603, P < 0.001), high-density lipoprotein cholesterol ( r = − 0.362, P < 0.001), serum potassium ( r = − 0.237, P = 0.004), plasma glucose ( r = 0.383, P < 0.001), total bilirubin ( r = 0.340, P < 0.001), serum amyloid A ( r = 0.58, P < 0.001), procalcitonin ( r = 0.345, P < 0.001), C-reactive protein ( r = 0.477, P < 0.001), lactate dehydrogenase ( r = 0.548, P < 0.001), aspartate aminotransferase ( r = 0.342, P < 0.001), alanine aminotransferase ( r = 0.264, P = 0.001), erythrocyte sedimentation rate ( r = 0.284, P = 0.001) and D-dimer ( r = 0.477, P < 0.001) . Conclusions With the following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.
【저자키워드】 COVID-19, SARS-CoV-2, Correlation analysis, prognostic indicator, 【초록키워드】 Coronavirus disease 2019, coronavirus, High-density lipoprotein cholesterol, cross-sectional, disease severity, Comorbidity, C-reactive protein, D-dimer, procalcitonin, Infectious disease, lactate dehydrogenase, Peripheral blood, Spread, Lymphocyte count, serum, Wuhan, Patient, albumin, Aspartate aminotransferase, Mild, plasma, age, Potassium, mortality rate, Critical, clinical feature, Glucose, ROC Curve, alanine aminotransferase, white cell, Critically ill patient, erythrocyte sedimentation rate, acute respiratory syndrome, severe patients, total bilirubin, serum amyloid, neutrophil count, single center, parameter, helping, biochemical marker, Result, analyzed, identify, caused, the disease, prevented, groups, biochemical parameter, with COVID-19, 【제목키워드】 disease severity, Characteristics, Wuhan, Analysis, biochemical,