This commentary explains the reasons for the extensive variations in pneumococcal penicillin resistance based on a literature review of pneumococcal penicillin-binding proteins, the pharmacodynamics and pharmacokinetics of beta-lactams, the risk factors associated with mortality, laboratory issues and challenges, including identification, susceptibility testing, and clinical reporting, and the management of invasive and noninvasive Streptococcus pneumoniae infections.
All Keywords
【저자키워드】 penicillin, PBP, meningeal and nonmeningeal break points, pneumococcal resistance,
【저자키워드】 penicillin, PBP, meningeal and nonmeningeal break points, pneumococcal resistance,