Management of chronic neuritis with a combination regimen of lower doses prednisolone and methotrexate: a brief report

[[[ Introduction: ]]] Recommended fixed duration prednisolone regimen was not found effective in the treatment of chronic neuritis. Alternate effective treatment was being sought to reduce the deformity in the field of leprosy. [[[ Objective: ]]] We wished to see whether a prolonged course of prednisolone and methotrexate could be of any help for them. [[[ Methodology: ]]] In 2012-2014, an open pilot clinical study was undertaken where three chronic neuritic patients were treated with lower doses prednisolone and methotrexate for 12 months and a follow up period was delivered for 12 months. The study was undertaken in one of the outdoor clinics of the university. [[[ Results: ]]] Complete and permanent remission of neuritis was achieved with appreciable functional recovery. Few mild self-limiting side-effects from prednisolone were observed and there was no side-effects from methotrexate. [[[ Conclusion: ]]] Prolonged course of prednisolone and methotrexate was found safe and effective in treating chronic neuritis.