Background A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. Methods In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. Results One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ± 20.17 ng/mL. In total, 62.7% ( n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% ( n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% ( n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection ( P > 0.05). Conclusions Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Vitamin D, insufficiency, Sufficiency, 【초록키워드】 Hospitalization, cross-sectional, Infection, Infectious disease, outcome, underlying disease, Laboratory, Clinical outcome, adverse outcome, Iran, COVID-19 infection, Patient, protective effect, Protective, COVID-19 patient, chronic, lower risk, vitamin D level, vitamin D sufficiency, Severity of infection, disorder, cutoff point, duration of hospitalization, multivariable, Result, greater, analyzed, was used, the patient, less, determine, suffered, statistically significant, infected with COVID-19, 【제목키워드】 vitamin D insufficiency, Infection, Clinical outcome, association, patients with COVID-19,