Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF^{-/-} mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF^{-/-} mice.
All Keywords
【저자키워드】 mice, real time PCR, Mycobacterium leprae, leprosy,
【저자키워드】 mice, real time PCR, Mycobacterium leprae, leprosy,