The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Korean Health Insurance Review and Assessment COVID-19 database for this nationwide retrospective cohort study. Among these, 686 patients with asthma were assessed by their severities and evaluated by the clinical outcome of COVID-19 compared to patients without asthma. Of 7272 adult COVID-19 patients, 686 with asthma and 6586 without asthma were compared. Asthma was not a significant risk factor for respiratory failure or mortality among all COVID-19 patients (odds ratio [OR] = 0.99, P = 0.997 and OR = 1.06, P = 0.759) after adjusting for age, sex, and the Charlson comorbidity score. However, a history of acute exacerbation (OR = 2.63, P = 0.043) was significant risk factors for death among COVID-19 patients with asthma. Asthma is not a risk factor for poor prognosis of COVID-19. However, asthma patients who had any experience of acute exacerbation in the previous year before COVID-19 showed higher COVID-19-related mortality, especially in case of old age and male sex.
【저자키워드】 Medical research, Risk factors, 【초록키워드】 COVID-19, coronavirus disease, Asthma, review, coronavirus, Respiratory failure, Mortality, severity, Comorbidities, Comorbidity, Sex, risk factor, database, Clinical outcome, Patient, death, age, assessment, Korean, Male sex, Odds ratio, COVID-19 patient, old age, Health Insurance, retrospective cohort study, insurance, acute exacerbation, potential risk, poor prognosis, asthma patients, adult COVID-19 patients, selected, evaluated, demonstrated, adult COVID-19 patient, asthma patient, were assessed, 【제목키워드】 COVID-19, Asthma, coronavirus, severity, Impact,