Background The novel coronavirus pandemic has had a differential impact on communities of color across the US. The University of California hospital system serves a large population of people who are often underrepresented elsewhere. Data from hospital stays can provide much-needed localized information on risk factors for severe cases and/or death. Methods Patient-level retrospective case series of laboratory-confirmed COVID-19 hospital admissions at five UC hospitals (N = 4730). Odds ratios of ICU admission, death, and a composite of both outcomes were calculated with univariate and multivariate logistic regression based on patient characteristics, including sex, race/ethnicity, and select comorbidities. Associations between comorbidities were quantified and visualized with a correlation network. Results Overall mortality rate was 7.0% (329/4,730). ICU mortality rate was 18.8% (225/1,194). The rate of the composite outcome (ICU admission and/or death) was 27.4% (1298/4730). Comorbidity-controlled odds of a composite outcome were increased for age 75–84 (OR 1.47, 95% CI 1.11–1.93) and 85–59 (OR 1.39, 95% CI 1.04–1.87) compared to 18–34 year-olds, males (OR 1.39, 95% CI 1.21–1.59) vs. females, and patients identifying as Hispanic/Latino (OR 1.35, 95% CI 1.14–1.61) or Asian (OR 1.43, 95% CI 1.23–1.82) compared to White. Patients with 5 or more comorbidities were exceedingly likely to experience a composite outcome (OR 2.74, 95% CI 2.32–3.25). Conclusions Males, older patients, those with multiple pre-existing comorbidities, and those identifying as Hispanic/Latino or Asian experienced an increased risk of ICU admission and/or death. These results are consistent with reported risks among the Hispanic/Latino population elsewhere in the United States, and confirm multiple concerns about heightened risk among the Asian population in California. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-021-06640-4.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, Hospitalization, Comorbidities, intensive care unit, in-hospital mortality, Composite outcome, 【초록키워드】 COVID-19, pandemic, hospital, Comorbidity, Sex, risk, outcome, risk factor, ICU, Novel coronavirus, Characteristics, male, Patient, ICU admission, death, Community, age, Hospital admission, mortality rate, correlation, information, retrospective, older patients, Hospital stay, Asian, supplementary material, 95% CI, increased risk, multivariate logistic regression, white, Severe case, laboratory-confirmed, The United States, females, FIVE, Result, reported, case sery, calculated, quantified, University of California, 【제목키워드】 COVID-19 hospitalization, retrospective cohort study, FIVE,