Background With pandemic of coronavirus disease 2019 (COVID-19), human coronaviruses (HCoVs) have recently attached worldwide attention as essential pathogens in respiratory infection. HCoV-229E has been described as a rare cause of lower respiratory infection in immunocompetent adults. Case presentation We reported a 72-year-old man infected by HCoV-229E with rapid progression to acute respiratory distress syndrome, in conjunction with new onset atrial fibrillation, intensive care unit acquired weakness, and recurrent hospital acquired pneumonia. Clinical and radiological data were continuously collected. The absolute number of peripheral T cells and the level of complement components diminished initially and recovered after 2 months. The patient was successfully treated under intensive support care and discharged from the hospital after 3 months and followed. Conclusion HCoV-229E might an essential causative agent of pulmonary inflammation and extensive lung damage. Supportive treatment was essential to HCoVs infection on account of a long duration of immunological recovery in critical HCoV-229E infection.
【저자키워드】 immunology, Pneumonia, adult respiratory distress syndrome, human coronavirus 229E, 【초록키워드】 COVID-19, Treatment, coronavirus disease, pandemic, intensive care, hospital, Infection, complement, progression, pulmonary inflammation, Atrial fibrillation, T cell, respiratory infection, pathogen, clinical, Patient, HCoV-229E, Intensive, Care, Critical, acute respiratory distress, Support, syndrome, weakness, component, immunological, immunocompetent adults, radiological, extensive lung damage, human coronavirus, described, collected, reported, treated, discharged, 【제목키워드】 Case report, Severe case, diabete,