Background Coronavirus disease (COVID-19) is rapidly spreading worldwide. Although 10–20% of patients with COVID-19 have severe symptoms, little is known about the risk factors related to the aggravation of COVID-19 symptoms from asymptomatic or mild to severe disease states. Methods This retrospective study included 211 patients who were asymptomatic or with mild presentations of COVID-19. We evaluated the differences in demographic and clinical data between the cured (discharged to home) and transferred (aggravated to severe-stage COVID-19) groups. Results A multivariate logistic analysis showed that body temperature, chills, initial chest X-ray findings, and the presence of diabetes were significantly associated with predicting the progression to severe stage of COVID-19 ( p < 0.05). The odds ratio of transfer in patients with COVID-19 increased by 12.7-fold for abnormal findings such as haziness or consolidation in initial chest X-ray, 6.32-fold for initial symptom of chills, and 64.1-fold for diabetes. Conclusions Even if patients are asymptomatic or have mild symptoms, clinicians should closely observe patients with COVID-19 presenting with chills, body temperature > 37.5 °C, findings of pneumonia in chest X-ray, or diabetes.
【저자키워드】 coronavirus disease, diabetes, Fever, chilling, Risk factor: symptom aggravation, 【초록키워드】 COVID-19, Pneumonia, progression, risk factor, Retrospective study, Asymptomatic, Patient, Mild, chest X-ray, disease, consolidation, body temperature, mild symptoms, Analysis, Odds ratio, severe disease, COVID-19 symptom, initial symptom, Logistic, clinician, Clinical data, severe symptoms, transfer, chills, initial, observé, Result, significantly, evaluated, groups, discharged, cured, presenting, diabete, patients with COVID-19, transferred, 【제목키워드】 Disease progression, COVID-19 patient, Factor,