Among the more recently identified SARS-CoV-2 Variants of Interest (VOI) is the Lambda variant, which emerged in Peru and has rapidly spread to South American regions and the US. This variant remains poorly investigated, particularly regarding the effects of mutations on the thermodynamic parameters affecting the stability of the Spike protein and its Receptor Binding Domain. We report here an in silico study on the potential impact of the Spike protein mutations on the immuno-escape ability of the Lambda variant. Bioinformatics analysis suggests that a combination of shortening the immunogenic epitope loops and the generation of potential N-glycosylation sites may be a viable adaptation strategy, potentially allowing this emerging viral variant to escape from host immunity.
【저자키워드】 SARS-CoV-2, Lambda variant, epitope loop shortening, N-glycosylation site, interaction energy, immunoevasion, 【초록키워드】 Mutation, variant, in silico, Protein, Region, stability, epitope, viral variant, Lambda, Combination, Analysis, host immunity, immunogenic, South, parameter, Effect, interest, spread to, investigated, affecting, the Spike, thermodynamic, 【제목키워드】 Lambda, shortening,