Purpose To assess patient characteristics associated with health-related quality of life (HR-QoL) and its mental and physical subcategories 3 months after diagnosis with COVID-19. Methods In this prospective multicentre cohort study, HR-QoL was assessed in 90 patients using the SF-36 questionnaire (36-item Short Form Health Survey), which consists of 8 health domains that can be divided into a mental and physical health component. Mental health symptoms including anxiety, depression, and post-traumatic stress disorders were evaluated using the Hospital Anxiety and Depression Scale (HADS) and Post-traumatic Stress Disorder Checklist-5 (PCL-5) 3 months after COVID-19. Using descriptive statistics and multivariable regression analysis, we identified factors associated with impaired HR-QoL 3 months after COVID-19 diagnosis. Results Patients were 55 years of age (IQR, 49–63; 39% women) and were classified as severe (23%), moderate (57%), or mild (20%) according to acute disease severity. HR-QoL was impaired in 28/90 patients (31%). Younger age [per year, adjOR (95%CI) 0.94 (0.88–1.00), p = 0.049], longer hospitalization [per day, adjOR (95%CI) 1.07 (1.01–1.13), p = 0.015], impaired sleep [adjOR (95%CI) 5.54 (1.2–25.61), p = 0.028], and anxiety [adjOR (95%CI) 15.67 (3.03–80.99), p = 0.001) were independently associated with impaired HR-QoL. Twenty-nine percent ( n = 26) scored below the normal range on the mental health component of the SF-36 and independent associations emerged for anxiety, depression, and self-reported numbness. Impairments in the physical health component of the SF-36 were reported by 12 (13%) patients and linked to hypogeusia and fatigue. Conclusion Every third patient reported a reduction in HR-QoL 3 months after COVID-19 diagnosis and impairments were more prominent in mental than physical well-being. Supplementary Information The online version contains supplementary material available at 10.1007/s11136-021-02998-9.
【저자키워드】 COVID-19, SARS-CoV-2, mental health, Quality of life, neuro-COVID, 【초록키워드】 Anxiety, Depression, Hospitalization, fatigue, survey, disease severity, Diagnosis, Symptom, cohort study, Health, Characteristics, Post-traumatic stress disorder, Patient, COVID-19 diagnosis, Mild, age, multicentre, women, scale, moderate, questionnaire, association, regression analysis, Hypogeusia, Factor, supplementary material, 95%CI, domain, impairment, HADS, Mental, physical, independent, multivariable, Result, reported, evaluated, form, reduction in, was impaired, IQR, patient reported, scored, with COVID-19, 【제목키워드】 Factor, diagnosed with COVID-19,