Background Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology. Methods We herein present data from the ongoing prospective, multicentre, observational CovILD cohort study (ClinicalTrials.gov number, NCT04416100), which systematically follows up patients after COVID-19. 109 participants were evaluated 60 days after onset of first COVID-19 symptoms including clinical examination, chest computed tomography and laboratory testing. Results We investigated subjects with mild to critical COVID-19, of which the majority received hospital treatment. 60 days after disease onset, 30% of subjects still presented with iron deficiency and 9% had anemia, mostly categorized as anemia of inflammation. Anemic patients had increased levels of inflammation markers such as interleukin-6 and C-reactive protein and survived a more severe course of COVID-19. Hyperferritinemia was still present in 38% of all individuals and was more frequent in subjects with preceding severe or critical COVID-19. Analysis of the mRNA expression of peripheral blood mononuclear cells demonstrated a correlation of increased ferritin and cytokine mRNA expression in these patients. Finally, persisting hyperferritinemia was significantly associated with severe lung pathologies in computed tomography scans and a decreased performance status as compared to patients without hyperferritinemia. Discussion Alterations of iron homeostasis can persist for at least two months after the onset of COVID-19 and are closely associated with non-resolving lung pathologies and impaired physical performance. Determination of serum iron parameters may thus be a easy to access measure to monitor the resolution of COVID-19. Trial registration ClinicalTrials.gov number: NCT04416100.
【저자키워드】 COVID-19, SARS-CoV-2, hepcidin, Iron metabolism, Hyperferritinemia, 【초록키워드】 Treatment, coronavirus disease, Inflammation, Anemia, hospital, interleukin-6, C-reactive protein, ferritin, cytokine, cohort study, Laboratory testing, Peripheral blood, Chest computed tomography, serum, hyperinflammation, Patient, Mild, multicentre, computed tomography scan, correlation, Critical, patients, Lung pathology, disease onset, performance status, mononuclear cell, deficiency, subject, alteration, individual, participant, increased mortality, first COVID-19 symptom, clinical examination, iron homeostasis, mRNA expression, MONITOR, parameter, physical, severe lung pathology, Course, Result, significantly, investigated, evaluated, majority, demonstrated, survived, Determination, inflammation marker, Still, 【제목키워드】 Lung pathology, alteration, iron homeostasis, prospective observational cohort,