Background Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. Methods This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO 2 /FiO 2 ratio were used to assess lung injury. Results 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO 2 /FiO 2 were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO 2 /FiO 2 (β = − 0.434, p = 0.003). Conclusions Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, Pneumonia, cytokine, Lung injury, 【초록키워드】 COVID-19, SARS-CoV-2, Necrosis, coronavirus, IL-6, severity, Infection, IL6, procalcitonin, Symptoms, Lymphocyte count, Retrospective study, serum, Characteristics, Patient, age, underlying diseases, demographic, disease, cytokine profile, COVID-19 patients, association, Analysis, acute respiratory syndrome, laboratory data, Elevation, disorder, variable, independent, log, Result, predicted, collected, caused, significantly, conducted, were used, correlated, significantly higher, circulating cytokine, PaO, with COVID-19, 【제목키워드】 COVID-19, cytokine profile,