Background Coronavirus disease 2019 (COVID-19) caused by a highly contagious virus called severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019 and became a major threat to health around the world. The health experts are still learning more about the detailed knowledge of the natural course and the severity of COVID-19. The study aimed to assess the prevalence and association of severity of disease with demographic characteristics, initial presenting symptoms, and comorbidities among COVID-19 patients in treatment centers, Myanmar. Methods A cross-sectional study was conducted at Hmawbi and Indine treatment centers, Yangon Region, Myanmar, from November to December 2020. Data were collected by using standardized case report forms and then, a total of 222 confirmed COVID-19 inpatients were included in this study. The odds ratio with a 95% confidence interval (CI) was used as a measure of association and the independent associated factors for severity of disease were investigated using logistic regression analysis. Results In total, 81.5% were symptomatic patients and of these, the most common presenting symptoms were fever 54.1%, loss of smell 50.3%, and cough 30.9%. Among 37.8% of COVID-19 patients with comorbidities, the most common comorbidities were hypertension 58.3%, diabetes mellitus 29.8%, and heart diseases 26.2%, respectively. As a severity, 20.7% of patients had signs of severe pneumonia. The associated factors of severe pneumonia were aged 60 years and older [Adjusted odds ratio (AOR) = 2.88, 95% CI 1.14–7.29] , overweight or obesity (AOR: 3.87, 95%CI 1.80–8.33), and current smoking (AOR: 6.74, 95% CI 2.72–16.75). Conclusions In this study, one-fifth of the patients developed severe pneumonia. The COVID-19 patients who were aged 60 years and older, overweight or obesity, and current smokers should be monitored carefully during the course of treatment to reduce the disease severity.
【저자키워드】 COVID-19, Pneumonia, severity, Comorbidities, Initial presenting symptoms, 【초록키워드】 Treatment, coronavirus, knowledge, cross-sectional, obesity, Diabetes Mellitus, Comorbidity, smoking, cough, virus, hypertension, Prevalence, China, Region, Health, severity of COVID-19, Fever, Patient, Severity of disease, severe pneumonia, disease, association, Odds ratio, heart disease, COVID-19 patient, demographic characteristics, presenting symptoms, presenting symptom, smoker, Inpatient, Loss of Smell, acute respiratory syndrome, Older, Factor, Logistic regression analysis, case report form, 95%CI, 95% CI, 95% confidence interval, contagious, Yangon, independent, initial, Course, Result, was used, collected, caused, the patient, investigated, the disease, conducted, reduce, symptomatic patient, 【제목키워드】 Comorbidity, Epidemic, severity of COVID-19, Patient, second wave, presenting symptoms,