Abstract Inflammation-mediated lung injury in severe cases of infection with SARS-CoV-2, the aetiological agent of Coronavirus disease 2019 (COVID-19), can lead to respiratory failure and death, and therapies that block or ameliorate lung injury-associated inflammatory “cytokine storms” and progression to acute respiratory distress syndrome (ARDS) are urgently needed. Therapeutic use of corticosteroids for this purpose has been controversial because of conflicting reports on their efficacy and immunosuppressive behaviour. The WHO has strongly recommended treating critical COVID-19 patients with systemic corticosteroid therapy, but recommends against corticosteroid therapy in non-severe COVID-19 disease because of a lack of strong evidence on its efficacy. This retrospective case report describing the successful treatment of a non-severe COVID-19 case in Changchun, China, by judicious administration of corticosteroids using a personalized therapeutic approach was recorded to strengthen the evidence base showing how corticosteroid use in non-severe COVID-19 cases can be safe and efficacious. Alongside supportive care and lopinavir/ritonavir antiviral drugs, a low dosage of methylprednisolone was administered over a short period to attenuate lung inflammation. Regular chest CT scans guided dosage reduction in response to lesion absorption and improved lung condition. Judicious use of corticosteroids safely attenuated disease progression and facilitated rapid and complete recovery.
【저자키워드】 Methylprednisolone, SARS-CoV-2, Cytokine storm, acute respiratory distress syndrome, Personalized medicine, 【초록키워드】 Corticosteroid, COVID-19, Treatment, Coronavirus disease 2019, Efficacy, ARDS, therapy, Respiratory failure, antiviral drugs, lung, Lung injury, progression, Case report, COVID-19 disease, China, Disease progression, death, WHO, acute respiratory distress, Evidence, retrospective, supportive care, Lung inflammation, Therapeutic approach, Inflammatory, immunosuppressive, chest CT scan, Safe, complete recovery, dosage, COVID-19 case, syndrome, Severe case, corticosteroid therapy, Administered, lack, facilitated, reduction in, attenuate, administration of corticosteroid, critical COVID-19 patient, infection with SARS-CoV-2, Regular, systemic corticosteroid, use of corticosteroid, was recorded, 【제목키워드】 Corticosteroid, Case report,