Intestinal epithelial organoids reflect the morphology and function of an in vivo epithelial barrier. The composition of epithelial cell types reflects the cellular composition of the original tissue (small or large intestine) and organoids can be grown from different species. Thus, intestinal organoids constitute an ideal model to investigate infections of different hosts with enteric pathogens. In this chapter, we will focus on Salmonella infection of human and mouse colonoids grown in a 2D monolayer on permeable filter supports.
All Keywords
【저자키워드】 Infection, Cell culture, organoids, Salmonella, Host–pathogen interaction, intestinal epithelial cells, in vitro model, Colonoids,
【저자키워드】 Infection, Cell culture, organoids, Salmonella, Host–pathogen interaction, intestinal epithelial cells, in vitro model, Colonoids,