Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.
All Keywords
【저자키워드】 neutralizing antibody, SARS-CoV-2, Innate immunity, type I interferon, trained immunity, mucosal immunity, T-cell immunity, Th1 responses, 【초록키워드】 Vaccine, Immunity, SARS-COV-2 infection, severity, Genetic, Infection, Local, immune responses, Factors, type I interferons, Viral transmission, disease, Neutralizing antibody titer, innate immune, mucosal, lower risk, current, robust, addition, facilitate, contribute, suggested, induce, effective vaccine, sustained, amelioration of disease, immune correlate, Th1 response, 【제목키워드】 protection, Potential,
【저자키워드】 neutralizing antibody, SARS-CoV-2, Innate immunity, type I interferon, trained immunity, mucosal immunity, T-cell immunity, Th1 responses, 【초록키워드】 Vaccine, Immunity, SARS-COV-2 infection, severity, Genetic, Infection, Local, immune responses, Factors, type I interferons, Viral transmission, disease, Neutralizing antibody titer, innate immune, mucosal, lower risk, current, robust, addition, facilitate, contribute, suggested, induce, effective vaccine, sustained, amelioration of disease, immune correlate, Th1 response, 【제목키워드】 protection, Potential,