Intercellular communication occurring by cell-to-cell contacts and via secreted messengers trafficked through extracellular vehicles is critical for regulating biological functions of multicellular organisms. Recent research has revealed that non-coding RNAs can be found in extracellular vesicles consistent with a functional importance of these molecular vehicles in virus propagation and suggesting that these essential membrane-bound bodies can be highjacked by viruses to promote disease pathogenesis. Newly emerging evidence that coronaviruses generate non-coding RNAs and use extracellular vesicles to facilitate viral pathogenicity may have important implications for the development of effective strategies to combat COVID-19, a disease caused by infection with the novel coronavirus, SARS-CoV-2. This article provides a short overview of our current understanding of the interactions between non-coding RNAs and extracellular vesicles and highlights recent research which supports these interactions as potential therapeutic targets in the development of novel antiviral therapies.
【저자키워드】 COVID-19, SARS-CoV, miRNA, Exosomes, lncRNA, extracellular vehicles, ectasomes, 【초록키워드】 SARS-CoV-2, Infection, Novel coronavirus, biological function, Research, extracellular vesicle, molecular, disease, Critical, Evidence, Interaction, Contact, antiviral therapies, multicellular organisms, Support, disease pathogenesis, potential therapeutic target, non-coding RNA, viral pathogenicity, membrane-bound, implication, recent, highlight, virus propagation, Extracellular, caused, virus, generate, facilitate, functional, provide, coronavirus, promote, effective strategy, secreted, 【제목키워드】 RNA, Mobility, target, candidate, insight, New,