Novel coronavirus disease (COVID-19) has led to a major public health crisis globally. Currently, myocardial damage is speculated to be associated with COVID-19, which can be seen as one of the main causes of death of patients with COVID-19. We therefore, aim to investigate the effects of COVID-19 disease on myocardial injury in hospitalized patients who have been tested positive for COVID-19 pneumonia in this study. A prospective study was conducted among 201 patients with COVID-19 in the Pakistan Military Hospital from April 1 to August 31, 2020, including non-critical cases and critical cases. COVID-19 patients were stratified as critical and non-critical according to the signs and symptoms severity; with those requiring intensive care and invasive mechanical ventilation as critical, and those did not requiring invasive mechanical ventilation as non-critical. A total of 201 COVID-19 patients with critical and non-critical categories presented with myocardial injury. All patients with myocardial injury had an elevation in CKMB and Troponin-I levels. Of these patients, 43.7% presented with new electrocardiography (ECG) changes, and ST depression was typically observed in 36.3% patients. In addition, 18.7% patients presented with abnormal echocardiography findings, with right ventricular dilatation and dysfunction commonly seen among critical group patients. Results analyzed by a logistic regression model showing COVID-19 direct contribution to myocardial injury in these patients. COVID-19 disease directly leads to cardiovascular damage among critical and non-critical patients. Myocardial injury is associated not only with abnormal ECG changes but also with myocardial dysfunction on echocardiography and more commonly observed among critical patients.
【저자키워드】 Cardiology, 【초록키워드】 COVID-19, coronavirus disease, COVID-19 pneumonia, intensive care, Pneumonia, Prospective Study, troponin, Symptom, public health crisis, hospitalized patients, novel coronavirus disease, Health crisis, Novel coronavirus, ECG, COVID-19 disease, echocardiography, myocardial injury, myocardial damage, Signs and symptoms, Patient, death, Electrocardiography, novel, change, Critical, patients, COVID-19 patients, Invasive mechanical ventilation, Injury, COVID-19 patient, Myocardial dysfunction, critical cases, leads, changes, dysfunction, ventricular dilatation, logistic regression model, Elevation, critical patients, cardiovascular damage, CKMB, ST depression, Troponin-I, positive, Effect, Result, tested, analyzed, addition, conducted, hospitalized patient, cause, category, stratified, patients with COVID-19, ventricular, with COVID-19, 【제목키워드】 Patient, disease, Critical, ST change,