Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within both individuals and populations. We validated a SARS-CoV-2 spike receptor binding domain serological test using 834 pre-pandemic samples and 31 samples from COVID-19 recovered donors. We then completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community. Over six percent of parturient women in Philadelphia (4 April–3 June 2020) had serological evidence of exposure to SARS-CoV-2.
【초록키워드】 COVID-19, serological test, SARS-CoV-2, IgG, IgM, Receptor binding domain, pregnant women, Pregnancy, Surveillance, Serological testing, nasopharyngeal, Community, Philadelphia, donors, women, SARS-CoV-2-specific antibodies, seropositive, Clinical practice, SARS-CoV-2 spike, individual, positive, parturient, serological evidence, over, populations, polymerase chain, affected, Limited, 【제목키워드】 SARS-CoV-2 seroprevalence, Philadelphia, women, parturient,