Introduction: Studies assessing immune responses following Pfizer-BioNTech BNT162b2 mRNA COVID-19 (Pfizer) and ChAdOx1 nCoV-19 AZD1222 (AstraZeneca) vaccines in patients with hemoglobinopathy are non-existent in the literature despite being thought at high risk of infection. Methods: Prospectively, we collected serum from patients with hemoglobinopathies at least 14 days post vaccine and measured neutralizing antibodies (nAb) in addition to binding antibodies using in-house assays. Results: All 66 participants mounted a significant binding antibody response (100%), but nAbs were detected in (56/66) post-vaccine with a rate of 84.5%. Age, gender, vaccine type, spleen status, hydroxyurea use, and hyperferritinemia did not affect the rate significantly. While 23/32 (71.8%) patients receiving only one dose of the vaccine were able to mount a positive response, 33/34 (97.05%) of those who had two doses of any vaccine type had a significant nAbs response. Patients who had anti-nucleocapsid (N), signifying asymptomatic infection in the past, were able to produce nAbs (31/31). No nAbs were detected in 10/35 (28.5%) patients with no anti-N antibodies. Conclusion: Our results provide supportive data when advising patients with hemoglobinopathy to receive COVID-19 vaccines and ensure booster doses are available for better immunity. Whenever available, measurement of nAb is recommended.
【저자키워드】 COVID-19, Vaccine, BNT162b2, Sickle cell disease, ChAdOx1 nCoV-19, thalassemia, 【초록키워드】 neutralizing antibody, COVID-19 vaccine, immune response, Immunity, Infection, Gender, Pfizer, serum, AZD1222, anti-N antibodies, Patient, asymptomatic infection, booster dose, Pfizer-BioNTech, spleen, AstraZeneca, BNT162b2 mRNA, NAb, Hyperferritinemia, dose, Hemoglobinopathy, binding antibody, high risk, participant, positive response, while, Post-vaccine, thought, collected, significantly, assays, addition, receiving, not affect, the vaccine, receive, mounted, 【제목키워드】 immunogenicity, mRNA,