(1) Background: Numerous vaccines are under preclinical and clinical development for prevention of severe course and lethal outcome of coronavirus disease 2019 (COVID-19). In light of high efficacy rates and satisfactory safety profiles, some agents have already reached approval and are now distributed worldwide, with varying availability. Real-world data on cutaneous adverse drug reactions (ADRs) remain limited. (2) Methods: We performed a literature research concerning cutaneous ADRs to different COVID-19 vaccines, and incorporated our own experiences. (3) Results: Injection site reactions are the most frequent side effects arising from all vaccine types. Moreover, delayed cutaneous ADRs may occur after several days, either as a primary manifestation or as a flare of a pre-existing inflammatory dermatosis. Cutaneous ADRs may be divided according to their cytokine profile, based on the preponderance of specific T-cell subsets (i.e., Th1, Th2, Th17/22, Tregs). Specific cutaneous ADRs mimic immunogenic reactions to the natural infection with SARS-CoV-2, which is associated with an abundance of type I interferons. (4) Conclusions: Further studies are required in order to determine the best suitable vaccine type for individual groups of patients, including patients suffering from chronic inflammatory dermatoses.
【저자키워드】 COVID-19, Vaccines, adverse event, Exanthema, 【초록키워드】 coronavirus disease, SARS-CoV-2, Efficacy, Vaccine, Th1, Th2, outcome, COVID-19 vaccines, Research, Patient, type I interferons, T-cell, group, natural infection, patients, Cutaneous, cytokine profile, ADRS, Adverse drug reaction, Inflammatory, Tregs, Side effect, reaction, profiles, approval, clinical development, injection site, Specific, Course, performed, required, arising, determine, occur, reached, subset, concerning, Numerous, ADR, immunogenic reaction, 【제목키워드】 Cutaneous, Adverse, reaction, insight,