The impact of a third dose of COVID-19 vaccine on antibody responses is unclear in immunocompromised patients. The objective of this retrospective study was to characterize antibody responses induced by a third dose of mRNA COVID-19 vaccine in 160 kidney transplant recipients and 20 patients treated for chronic lymphocytic leukemia (CLL). Prevalence of anti-spike IgG ≥ 7.1 and ≥ 30 BAU/mL after the third dose were 47% (75/160) and 39% (63/160) in kidney transplant recipients, and 57% (29/51) and 50% (10/20) in patients treated for CLL. Longitudinal follow-up identified a moderate increase in SARS-CoV-2 anti-spike IgG levels after a third dose of vaccine in kidney transplant recipients (0.19 vs. 5.28 BAU/mL, p = 0.03) and in patients treated for CLL (0.63 vs. 10.7 BAU/mL, p = 0.0002). This increase in IgG levels had a limited impact on prevalence of anti-spike IgG ≥ 30 BAU/mL in kidney transplant recipients (17%, 2/12 vs. 33%, 4/12, p = 0.64) and in patients treated for CLL (5%, 1/20 vs. 45%, 9/20, p = 0.008). These results highlight the need for vaccination of the general population and the importance of non-medical preventive measures to protect immunocompromised patients.
【저자키워드】 COVID-19, Vaccine, antibody, chronic lymphocytic leukemia, kidney transplant, 【초록키워드】 COVID-19 vaccine, vaccination, Antibody Response, Immunocompromised patients, Prevalence, Retrospective study, anti-Spike IgG, mRNA, CLL, Follow-up, General population, longitudinal, moderate, leukemia, kidney transplant recipient, kidney transplant recipients, dose, preventive measure, SARS-CoV-2 anti-spike IgG, highlight, PROTECT, increase in, IgG level, patients treated, 【제목키워드】 Transplant, response, chronic, recipient,