The COVID-19 pandemic has led to health, social and economic consequences for public health systems. As a result, the development of safe and effective vaccines, in order to contain the infection quickly became a priority. The first vaccine approved by the Italian Agency for Drugs Authorization (AIFA) was the BNT162b2 mRNA vaccine, developed by BioNTech and Pfizer (Comirnaty). Comirnaty contains a molecule called messenger RNA (mRNA), which is a nucleoside-modified RNA that encodes the SARS-CoV-2 spike glycoprotein. Even if data from phase I suggest that vaccine induced antibodies can persist for up to six months following the second shot of BNT vaccine, data regarding the real duration of immunological protection are lacking. In this study, we aimed to evaluate the duration of serological protection by detecting the presence of anti-S-RBD (receptor-binding domain) antibodies for SARS-CoV-2 among a large group of healthcare workers (HCWs) three months after vaccination. 99% of HCWs had a detectable titre of anti-S SARS-CoV-2 antibodies 90 days after the second vaccine shot. Elderly operators showed significantly lower levels of protective antibodies when compared to the younger ones, thus they could become unprotected earlier than other operators.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, Healthcare workers, mRNA vaccine, anti-S-RBD antibodies, 【초록키워드】 vaccination, Phase I, antibody, COVID-19 pandemic, elderly, spike glycoprotein, Infection, drug, healthcare worker, Pfizer, Health, SARS-CoV-2 antibody, HCWs, mRNA, serological, BNT162b2 mRNA vaccine, Protective antibody, Safe, HCW, Messenger RNA, domain, Effective vaccines, titre, authorization, anti-S, operator, public health systems, operators, ENCODE, significantly lower, AIFA, Italian, consequence, immunological protection, evaluate, detectable, approved, BNT, nucleoside-modified RNA, the SARS-CoV-2, 【제목키워드】 BNT162b2 mRNA, worker,