BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Efficacy, immunogenicity, mRNA vaccine, challenge study, 【초록키워드】 neutralizing antibody, immunization, viral clearance, hACE2, Anti-viral, BNT162b2, mice, protective effect, viral challenge, lung lesion, transgenic mice, Prevent, approved, correlated, elicited, of BNT162b2, 【제목키워드】 hACE2, BNT162b2, encoding, the SARS-CoV-2,
【저자키워드】 COVID-19, SARS-CoV-2, Efficacy, immunogenicity, mRNA vaccine, challenge study, 【초록키워드】 neutralizing antibody, immunization, viral clearance, hACE2, Anti-viral, BNT162b2, mice, protective effect, viral challenge, lung lesion, transgenic mice, Prevent, approved, correlated, elicited, of BNT162b2, 【제목키워드】 hACE2, BNT162b2, encoding, the SARS-CoV-2,