Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, reports of sarcoidosis or LS after vaccination have not been published. Here, we report two cases of de novo LS in a temporal association with different vaccines against the new coronavirus SARS-CoV-2. One patient developed the first symptoms three days after the second vaccination (first vaccination ChadOx-1, Astra Zeneca; second vaccination CX-024414, Moderna); in the second patient, symptoms started 28 days after the first vaccination (ChadOx-1, Astra Zeneca). Both patients eventually required treatment with glucocorticoids. Both patients achieved clinical improvement with treatment. In conclusion, we report the first two cases of LS shortly after SARS-CoV-2 vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, sarcoidosis, Löfgren’s syndrome, 【초록키워드】 Treatment, Glucocorticoids, Vaccine, Symptom, Patient, Clinical improvement, SARS-CoV-2 vaccination, association, reaction, second vaccination, one patient, syndrome, first vaccination, new coronavirus SARS-CoV-2, de novo, Astra Zeneca, Course, addition, required, first symptom, 【제목키워드】 report,