The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was shown that the magnitude of the neutralizing antibody (NAbs) response correlates with the degree of protection. However, the difference between the immune response in naïve mRNA-vaccinated and previously infected (PI) individuals is not well studied. We investigated the level of NAbs in naïve and PI individuals after 1 to 26 (median = 6) weeks of the second dose of BNT162b2 or mRNA-1273 vaccination. The naïve mRNA-1273 vaccinated group ( n = 68) generated significantly higher (~2-fold, p ≤ 0.001) NAbs than the naïve BNT162b2 ( n = 358) group. The P -vaccinated group ( n = 42) generated significantly higher (~3-fold; p ≤ 0.001) NAbs levels than the naïve-BNT162b2 ( n = 426). Additionally, the older age groups produced a significantly higher levels of antibodies than the young age group (<30) ( p = 0.0007). Our results showed that mRNA-1273 generated a higher NAbs response than the BNT162b2 vaccine, and the PI group generated the highest level of NAbs response regardless of the type of vaccine.
【저자키워드】 SARS-CoV-2, Vaccine, Neutralizing antibodies, Moderna-mRNA-1273, Pfizer-BNT162b2, 【초록키워드】 COVID-19, neutralizing antibody, BNT162b2 vaccine, immune response, vaccination, mRNA-1273, BNT162b2, Spread, protective immunity, Older age, age, group, NAb, second dose, individual, NAbs, naïve, mRNA COVID-19 vaccines, offer, produced, highest, shown, investigated, median, reducing, magnitude, significantly higher, levels of antibody, of BNT162b2, 【제목키워드】 mRNA-1273, response, assessment, Comparative, of BNT162b2,