The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation.
【저자키워드】 COVID-19 vaccination, Inactivated vaccine, herpetic keratitis, 【초록키워드】 COVID-19, Vaccine development, COVID-19 vaccine, pandemic, Antiviral, risk, virus, Endotheliitis, COVID-19 vaccines, Patient, latency, herpes simplex keratitis, Sinovac, inactivated, clinician, triggering, ocular, Penetrating, Corneal, occurred, caused, reported, receiving, treated, suggested, the vaccine, accelerated, scarring, 【제목키워드】 COVID-19, keratitis,