The COVID-19 pandemics has caused the death of almost six million people worldwide. In order to establish collective immunity, the first vaccines that were approved in Germany were the vector virus-based vaccine Vaxzevria and the mRNA vaccines Comirnaty and Spikevax, respectively. As it was reported that SARS-CoV-2 can trigger autoimmunity, it is of significant interest to investigate whether COVID-19 vaccines evoke the formation of autoantibodies and subsequent autoimmunity. Here, we analyzed immune responses after different vaccination regimens (mRNA/mRNA, Vector/Vector or Vector/mRNA) with respect to anti-SARS-CoV-2-specific immunity and the development of autoantibodies well known for their appearance in distinct autoimmune diseases. We found that anti-SARS-CoV-2 antibody levels were 90% lower after Vector/Vector vaccination compared to the other vaccinations and that Vector/mRNA vaccination was more effective than mRNA/mRNA vaccination in terms of IgM and IgA responses. However, until 4 months after booster vaccination we only detected increases in autoantibodies in participants with already pre-existing autoantibodies whereas vaccinees showing no autoantibody formation before vaccination did not respond with sustained autoantibody production. Taken together, our study suggests that all used COVID-19 vaccines do not significantly foster the appearance of autoantibodies commonly associated with lupus erythematodes, rheumatoid arthritis, Celiac disease and antiphospholipid-syndrome but provide immunity to SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Autoimmunity, celiac disease, COVID-19 vaccination, Antiphospholipid syndrome, CCP, collagenosis, 【초록키워드】 IgM, Vaccine, COVID-19 vaccine, immune response, vaccination, Immunity, mRNA vaccine, rheumatoid arthritis, anti-SARS-CoV-2 antibody, Germany, death, Pandemics, Autoimmune diseases, booster vaccination, autoantibody, regimen, participant, IgA responses, effective, vaccinee, analyzed, caused, significantly, reported, subsequent, approved, respond, sustained, increases in, 【제목키워드】 Lupus, Rheumatoid, Formation, Accompanying,