Two mRNA COVID-19 vaccines (mRNA-1273, Moderna; and BNT162b2, Pfizer-BioNTech) and one viral vector vaccine (JNJ-78436735, Janssen/Johnson and Johnson) are authorized in the US to hinder COVID-19 infections. We analyzed severe and common adverse events in response to COVID-19 vaccines using real-world, Vaccine Adverse Effect Reporting System (VAERS) data. From 14 December 2020 to 30 September 2021, 481,172 (50.7 ± 17.5 years, males 27.89%, 12.35 per 100,000 people) individuals reported adverse events (AEs). The median time to severe AEs was 2 days after injection. The risk of severe AEs following the one viral vector vaccine (OR = 1.044, 95% CI = 1.005–1.086) was significantly higher than that after the two mRNA vaccines, and the risk among males (OR = 1.374, 95% CI = 1.342–1.406) was higher than among females, except for anaphylaxis. For common AEs, however, the risk to males (OR = 0.621, 95% CI = 0.612–0.63) was lower than to females. In conclusion, we provided medical insight and clinical guidance about vaccine types by characterizing AEs using real-world data. In particular, COVID-19 mRNA vaccines are safer than viral vector vaccines with regard to coagulation disorders, whereas inflammation-related AEs are lower in the viral vaccine. The risk–benefit ratio of vaccines should be carefully considered, and close monitoring and management of severe AEs is needed.
【저자키워드】 COVID-19, Safety, Vaccines, severe adverse events, 【초록키워드】 Vaccine, COVID-19 vaccine, mRNA-1273, risk, real-world data, mRNA vaccines, BNT162b2, management, adverse event, male, Reporting, Pfizer-BioNTech, Guidance, anaphylaxis, COVID-19 mRNA vaccine, Viral vector vaccine, coagulation disorders, mRNA COVID-19 vaccine, Adverse, 95% CI, median time, COVID-19 infections, individual, injection, close monitoring, JNJ-78436735, Effect, females, System, analyzed, reported, provided, significantly higher, AEs, severe AE, severe and common, 【제목키워드】 mRNA-1273, BNT162b2, monitoring, Adverse, JNJ-78436735,