We aimed to assess the effectiveness and safety of coronavirus disease 2019 (COVID-19) vaccines for pregnant women in real-world studies. We searched for observational studies about the effectiveness and safety of COVID-19 vaccines among vaccinated pregnant women from inception to 6 November 2021. A total of 6 studies were included. We found that vaccination prevented pregnant women from SARS-CoV-2 infection (OR = 0.50, 95% CI, 0.35–0.79) and COVID-19-related hospitalization (OR = 0.50, 95% CI, 0.31–0.82). Messenger-RNA vaccines could reduce the risk of infection in pregnant women (OR = 0.13, 95% CI, 0.03–0.57). No adverse events of COVID-19 vaccination were found on pregnant, fetal, or neonatal outcomes. Our analysis confirmed the effectiveness and safety of COVID-19 vaccines for pregnant women. Policy makers should formulate targeted strategies to improve vaccine coverage in pregnant women.
【저자키워드】 Meta-analysis, COVID-19 vaccine, Safety, systematic review, Pregnancy, Effectiveness, 【초록키워드】 COVID-19, coronavirus disease, Vaccine, vaccination, Hospitalization, SARS-COV-2 infection, observational study, Policy, pregnant women, outcomes, Coverage, COVID-19 vaccination, adverse event, pregnant, Analysis, risk of infection, Neonatal, 95% CI, IMPROVE, searched, reduce, prevented, fetal, 【제목키워드】 COVID-19, review,