This mini-review focuses on the mechanisms of how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) affects the brain, with an emphasis on the role of the spike protein in patients with neurological symptoms. Following infection, patients with a history of neurological complications may be at a higher risk of developing long-term neurological conditions associated with the α-synuclein prion, such as Parkinson’s disease and Lewy body dementia. Compelling evidence has been published to indicate that the spike protein, which is derived from SARS-CoV-2 and generated from the vaccines currently being employed, is not only able to cross the blood–brain barrier but may cause inflammation and/or blood clots in the brain. Consequently, should vaccine-induced expression of spike proteins not be limited to the site of injection and draining lymph nodes there is the potential of long-term implications following inoculation that may be identical to that of patients exhibiting neurological complications after being infected with SARS-CoV-2. However, further studies are needed before definitive conclusions can be made.
【저자키워드】 Cytokines, Angiotensin-converting enzyme 2 (ACE2), Spike protein, Parkinson’s disease, Blood–brain barrier (BBB), Lewy body dementia, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), novel coronavirus disease that emerged in 2019 (COVID-19), good laboratory practice, 【초록키워드】 SARS-CoV-2, Inflammation, Infection, Brain, Dementia, Patient, Neurological symptoms, cross, expression, mechanism, Evidence, Parkinson’s disease, neurological, Neurological complication, blood clot, higher risk, injection, Affect, implication, condition, the spike protein, the vaccine, draining lymph node, exhibiting, infected with SARS-CoV-2, Lewy body, 【제목키워드】 respiratory,